Abstract Title:

Tumor regression after intravenous administration of targeted vesicles entrapping the vitamin Eα-tocotrienol.

Abstract Source:

J Control Release. 2017 Jan 28 ;246:79-87. Epub 2016 Dec 18. PMID: 27993600

Abstract Author(s):

Reatul Karim, Sukrut Somani, Majed Al Robaian, Margaret Mullin, Rumelo Amor, Gail McConnell, Christine Dufès

Article Affiliation:

Reatul Karim


The therapeutic potential of tocotrienol, a member of the vitamin E family of compounds with potent in vitro anti-cancer properties, is limited by its inability to specifically reach tumors following intravenous administration. The purpose of this study is to determine whether a novel tumor-targeted vesicular formulation of tocotrienol would suppress the growth of A431 epidermoid carcinoma and B16-F10 melanoma in vitro and in vivo. In this work, we demonstrated that novel transferrin-bearing multilamellar vesicles entrappingα-T3 resulted in a dramatically improved (by at least 52-fold) therapeutic efficacy in vitro on A431 cell line, compared to the free drug. In addition, the intravenous administration of tocotrienol entrapped in transferrin-bearing vesicles resulted in tumor suppression for 30% of A431 and 60% of B16-F10 tumors, without visible toxicity. Mouse survival was enhanced by>13days compared to controls administered with the drug solution only. This tumor-targeted, tocotrienol-based nanomedicine therefore significantly improved the therapeutic response in cancer treatment.

Study Type : Animal Study, In Vitro Study

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