Tween 80 exposure in newborn rats results in disruption of female reproductive organs. - GreenMedInfo Summary

Abstract Title:

Delayed effects of neonatal exposure to Tween 80 on female reproductive organs in rats.

Abstract Source:

Food Chem Toxicol. 1993 Mar;31(3):183-90. PMID: 8473002

Abstract Author(s):

M Gajdová, J Jakubovsky, J Války

Article Affiliation:

Institute of Preventive and Clinical Medicine, Limbová, Bratislava.

Abstract:

Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or 10% aqueous solution on days 4-7 after birth. Treatment with Tween 80 accelerated maturation, prolonged the oestrus cycle, and induced persistent vaginal oestrus. The relative weight of the uterus and ovaries was decreased relative to the untreated controls. Squamous cell metaplasia of the epithelial lining of the uterus and cytological changes in the uterus were indicative of chronic oestrogenic stimulation. Ovaries were without corpora lutea, and had degenerative follicles.

Article Published Date : Mar 01, 1993
Study Type : Animal Study
Additional Links
Problem Substances : Adjuvant : CK(20) : AC(7), Tween 80 : CK(2) : AC(1)
Adverse Pharmacological Actions : Carcinogenic : CK(1052) : AC(159), Endocrine Disruptor : CK(529) : AC(106)

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Key Research Topics

Adverse Pharmacological Actions

Carcinogenic
Endocrine Disruptor

Toxic Ingredients

Adjuvant
Tween 80

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