Abstract Title:

Unusual cadinane-type sesquiterpene glycosides withα-glucosidase inhibitory activities from the fruit of Cornus officinalis Sieb. et Zuuc.

Abstract Source:

Bioorg Chem. 2019 02 ;82:1-5. Epub 2018 Sep 20. PMID: 30267969

Abstract Author(s):

Jun He, Jie-Kun Xu, Xue-Ge Pan, Xian-Sheng Ye, Pin-Yi Gao, Yu Yan, Chun-Yang Xu, Gui-Fen Qiang, Guan-Hua Du, Yung-Chi Cheng, Wei-Ku Zhang

Article Affiliation:

Jun He


Five novel and rare cadinane-type sesquiterpene glycosides, cornucadinoside A-E (1-5) were isolated from water extract of the fruit of Cornus officinalis Sieb. et Zuuc.. The new chemical structures, together with their absolute configurations, were elucidated on the basis of extensive spectroscopic analysis, including a comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. Their structures, which possess a naphthalene skeleton, are the first report on the occurrence of cadinane sesquiterpene glycosides in Cornus. Additionally, all the compounds exhibited markedα-glucosidase inhibitory activity except for 3in vitro.

Study Type : In Vitro Study

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