Ursolic acid can alleviate the memory impairments induced by Aβ25-35 in mice. - GreenMedInfo Summary
Ursolic acid attenuates beta-amyloid-induced memory impairment in mice.
Arq Neuropsiquiatr. 2016 Jun ;74(6):482-8. PMID: 27332074
OBJECTIVE: Increasing evidence demonstrates that oxidative stress and inflammatory are involved in amyloidβ (Aβ)-induced memory impairments. Ursolic acid (UA), a triterpenoid compound, has potent anti-inflammatory and antioxidant activities. However, it remains unclear whether UA attenuates Aβ-induced neurotoxicity.
METHOD: The aggregated Aβ25-35 was intracerebroventricularly administered to mice.
RESULTS: We found that UA significantly reversed the Aβ25-35-induced learning and memory deficits. Our results indicated that one of the potential mechanisms of the neuroprotective effect was attenuating the Aβ25-35-induced accumulation of malondialdehyde (MDA) and depletion of glutathione (GSH) in the hippocampus. Furthermore, UA significantly suppressed the upregulation of IL-1β, IL-6, and tumor necrosis-α factor levels in the hippocampus of Aβ25-35-treated mice.
CONCLUSION: These findings suggest that UA prevents memory impairment through amelioration of oxidative stress, inflammatory response and may offer a novel therapeutic strategy for the treatment of Alzheimer's disease.