Ursolic acid extracted from loquat inhibits aflatoxin-induced mutagenicity. - GreenMedInfo Summary

Abstract Title:

Ursolic acid inhibits aflatoxin B1-induced mutagenicity in a Salmonella assay system.

Abstract Source:

Biol Pharm Bull. 1994 Jul;17(7):990-2. PMID: 8000393

Abstract Author(s):

H S Young, H Y Chung, C K Lee, K Y Park, T Yokozawa, H Oura

Article Affiliation:

Department of Pharmacy, Pusan National University, Korea.

Abstract:

An attempt was made to isolate the active component of Eriobotrya japonica, which inhibits aflatoxin B1-induced mutagenicity in the Salmonella assay system. The number of revertants per plate was significantly decreased when a MeOH extract of Eriobotrya japonica was added to the assay system using Salmonella typhimurium TA100 or TA98. Furthermore, we examined the effect of each fraction purified from the MeOH extract, and an EtOAc fraction was found to be the most effective. Ursolic acid isolated from the EtOAc fraction markedly and significantly decreased the numbers of Salmonella typhimurium TA100 revertants per plate, thus showing antimutagenic activity.

Article Published Date : Jul 01, 1994

Study Type : In Vitro Study

Additional Links

Substances : Loquat : CK(121) : AC(60), Ursolic Acid : CK(366) : AC(233)

Diseases : Aflatoxicosis : CK(288) : AC(105), DNA damage : CK(2233) : AC(810)

Pharmacological Actions : Antimutagenic Agents : CK(217) : AC(137), Genoprotective : CK(519) : AC(200)

Additional Keywords : Plant Extracts : CK(18030) : AC(6699)

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.

Printer-friendly version

Ursolic acid extracted from loquat inhibits aflatoxin-induced mutagenicity. - GreenMedInfo Summary

Print Options

Key Research Topics

Substance

Disease

Pharmacological Actions

Subscribe to our informative Newsletter & receive Cancer Fighting Foods Ebook

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.