Abstract Title:

Proton pump inhibitors and risk for recurrent ischemic events or death in outpatients with symptomatic artery disease.

Abstract Source:

Atherosclerosis. 2019 Nov 16 ;292:84-89. Epub 2019 Nov 16. PMID: 31785493

Abstract Author(s):

Juan F Sánchez Muñoz-Torrero, Jose Zamorano, Sergio Rico-Martín, Maria D Rivas, Maria Asunción Bacaicoa, Roberto Robles, Carmen Sanchez-Bacaicoa, Manuel Monreal,

Article Affiliation:

Juan F Sánchez Muñoz-Torrero


BAGKGROUND AND AIMS: The influence of proton pump inhibitors (PPIs) on outcome in patients with symptomatic artery disease remains controversial.

METHODS: FRENA is a prospective registry of consecutive outpatients with symptomatic coronary (CAD), cerebrovascular (CVD) or peripheral artery disease (PAD). We compared the risk for subsequent ischemic events or death according to the use of PPIs.

RESULTS: As of December 2016, 5170 patients were recruited: 1793 (35%) had CAD, 1530 (30%) CVD and 1847 (35%) had PAD. Overall, 2289 patients (44%) were regularly using PPIs. During a median follow-up of 36 months, 172 patients suffered a recurrent myocardial infarction, 139 had ischemic stroke, 71 underwent limb amputation and 267 died (cardiovascular death, 109). On multivariable analysis, patients using PPIs were at a lower risk for subsequent limb amputation (hazard ratio [HR]: 0.53; 95%CI: 0.30-0.94), a similar risk for myocardial infarction (HR: 0.78; 95%CI: 0.55-1.10) or stroke (HR: 0.93; 95%CI: 0.64-1.35) and at a higher risk of death (HR: 1.37; 95%CI: 1.04-1.79).

CONCLUSIONS: Among stable outpatients with symptomatic artery disease, the use of PPIs was associated with a lower risk for subsequent ischemic events but a higher risk for death.

Study Type : Human Study
Additional Links

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.