Abstract Title:

Risk of immune hemolytic anemia in children following immunization.

Abstract Source:

Vaccine. 2009 Dec 9;27(52):7394-7. Epub 2009 Sep 18. PMID: 19766577

Abstract Author(s):

Allison L Naleway, Edward A Belongia, James G Donahue, Burney A Kieke, Jason M Glanz,

Article Affiliation:

The Center for Health Research, Kaiser Permanente Northwest, 3800 N Interstate Ave, Portland, OR 97227, United States. [email protected]


Several case reports have described immune hemolytic anemia (IHA) following vaccination in children. We examined the risk of IHA in the 42 days following vaccination exposure using a self-controlled case series study design. In our population-based cohort of nearly 4.5 million children in the Vaccine Safety Datalink, we identified 55 confirmed cases of new-onset IHA from 1991 through 2000. We found no association between IHA and diphtheria-pertussis-tetanus vaccination (incidence rate ratio (IRR)=0.65, 95% CI: 0.19-2.24), hepatitis B vaccination (IRR=1.73, 95% CI: 0.59-5.01), or any vaccination (IRR=1.04, 95% CI: 0.46-2.32).

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