Abstract Title:

New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix.

Abstract Source:

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2807-10. PMID: 12270151

Abstract Author(s):

Nobutoshi Murakami, Ying Ye, Motoyuki Kawanishi, Shunji Aoki, Nobuaki Kudo, Minoru Yoshida, Emi E Nakayama, Tatsuo Shioda, Motomasa Kobayashi

Article Affiliation:

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, Japan.


Bioassay-guided separation by use of the fission yeast expressing NES of Rev, a HIV-1 viral regulatory protein, resulted in isolation of valtrate (1) as a new Rev-transport inhibitor from the nucleus to cytoplasm from Valerianae Radix. Valtrate (1) also inhibited the p-24 production of HIV-1 virus without showing any cytotoxicity against the host MT-4 cells.

Study Type : In Vitro Study

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