Abstract Title:

Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea.

Abstract Source:

J Nat Prod. 2003 Feb;66(2):263-8. PMID: 12608862

Abstract Author(s):

Hong-Jie Zhang, Ghee Teng Tan, Vu Dinh Hoang, Nguyen Van Hung, Nguyen Manh Cuong, D Doel Soejarto, John M Pezzuto, Harry H S Fong

Article Affiliation:

Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry, University of Illinois at Chicago, Chicago, Illinois 60612, USA.


In a continuing search for anti-HIV compounds from plants of Vietnam, 19 compounds, including a new triterpene, were isolated from an extract of the leaves and stem of Vatica cinerea. The new triterpene was determined to be a cycloartane triterpenoid with 29 skeletal carbons and was assigned the name vaticinone (1). The known triterpenes included three cycloartanes, a lanostane, two dammaranes, three lupanes, an ursane, and an oleanane. A chlorophyll isolate was identified as pheophorbide a (13). The majority of the triterpenes, the sesquiterpene, 1-hydroxycyclocolorenone, and pheophorbide a showed anti-HIV activity, with the chlorophyll being the most active, demonstrating an IC(50) value of 1.5 microgram/mL (2.5 microM), while being completely devoid of toxicity up to a concentration of 20 microgram/mL (33.8 microM). Vaticinone (1) was found to inhibit the replication of HIV-1, with an IC(50) value of 6.5 microgram/mL (15.3 microM; selective index = 1.4). The structures of these isolates were determined by spectral data including 1D and 2D NMR spectra.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anti-HIV Agents : CK(133) : AC(84)

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