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Abstract Title:

Velvet Antler Methanol Extracts Ameliorate Parkinson's Disease by Inhibiting Oxidative Stress and Neuroinflammation: Fromto Mice.

Abstract Source:

Oxid Med Cell Longev. 2021 ;2021:8864395. Epub 2021 Jan 8. PMID: 33505591

Abstract Author(s):

Ying Liu, Hongyuan Li, Yunfei Li, Min Yang, Xiaohui Wang, Yinghua Peng

Article Affiliation:

Ying Liu

Abstract:

Velvet antler is the traditional tonic food or medicine used in East Asia for treating aging-related diseases. Herein, we try to dissect the pharmacology of methanol extracts (MEs) of velvet antler on Parkinson's disease (PD).studies showed that MEs decreased the aggregation of-synuclein and protected oxidative stress-induced DAergic neuron degeneration.cellular data indicated that MEs suppressed the LPS-induced MAPKs and NF-B activation, therefore inhibiting overproduction of reactive oxygen species, nitric oxide, tumor necrosis factor-, and interleukin-6; blocking microglia activation; and protecting DAergic neurons from the microglia-mediated neurotoxicity.MPTP-induced PD mouse investigations found that MEs prevented MPTP-induced neuron loss in the substantia nigra and improved the behavioral rotating rod performance in MPTP-treated mice by increasing the expression level of tyrosine hydroxylase (TH) and downregulating-synuclein protein expression. In all, these results demonstrate that MEs ameliorate PD by inhibiting oxidative stress and neuroinflammation.

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