Article Publish Status: FREE
Abstract Title:

Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers.

Abstract Source:

Mol Pharmacol. 2016 Mar ;89(3):376-87. Epub 2015 Dec 23. PMID: 26700563

Abstract Author(s):

Xiaoran Zhao, Hongen Li, Jianfeng Wang, Yan Guo, Bowen Liu, Xuming Deng, Xiaodi Niu

Article Affiliation:

Xiaoran Zhao


Pneumolysin (PLY), an essential virulence factor of Streptococcus pneumoniae (pneumococcus), can penetrate the physical defenses of the host and possesses inflammatory properties. The vital role PLY plays in pneumococcus pathogenesis makes this virulence factor one of the most promising targets for the treatment of pneumococcal infection. Verbascoside (VBS) is an agent that does not exhibit bacteriostatic activity but has been shown to inhibit PLY-mediated cytotoxicity. The results from molecular dynamics simulations and mutational analysis indicated that VBS binds to the cleft between domains 3 and 4 of PLY, thereby blocking PLY's oligomerization and counteracting its hemolytic activity. Moreover, VBS can effectively alleviate PLY-mediated human alveolar epithelial (A549) cell injury, and treatment with VBS provides significant protection against lung damage and reduces mortality in a pneumococcal pneumonia murine model. Our results demonstrate that VBS is a strong candidate as a novel therapeutic in the treatment of Streptococcus pneumoniae infection.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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