Abstract Title:

Viewing a humorous film decreases IgE production by seminal B cells from patients with atopic eczema.

Abstract Source:

J Psychosom Res. 2009 Feb;66(2):173-5. Epub 2008 Nov 22. PMID: 19154860

Abstract Author(s):

Hajime Kimata


OBJECTIVE: Sperms induced IgE production by seminal B cells from patients with atopic eczema via interaction of B cells with galectin-3 on sperms. We studied the effect of viewing a humorous film on IgE production by seminal B cells cultured with sperms. METHODS: Twenty-four male patients with atopic eczema viewed a humorous film (Modern Times, featuring Charlie Chaplin). Just before and immediately after viewing, semen was collected, and seminal B cells and sperms were purified. Seminal B cells were cultured with sperms and IgE production was measured, while expression of galectin-3 on sperms was assessed. RESULTS: After viewing the humorous film, IgE production by B cells cultured with sperms was significantly decreased. Moreover, expression of galectin-3 on sperms was reduced. CONCLUSION: Viewing a humorous film reduced galectin-3 expression on sperms, which in turn decreased IgE production by seminal B cells cultured with sperms. These results indicate that viewing a humorous film may be helpful for the study and treatment of local IgE production and allergy in the reproductive tract.

Study Type : Human Study
Additional Links
Therapeutic Actions : Laughter/Humor : CK(209) : AC(27)

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