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Abstract Title:

Vitamin BSupplementation and NT-proBNP Levels in COPD Patients: A Secondary Analysis of a Randomized and Controlled Study in Rehabilitation.

Abstract Source:

Front Neurosci. 2020 ;14:740. Epub 2020 Jul 14. PMID: 32760247

Abstract Author(s):

Fernanda Viana Paulin, Leandro Steinhorst Goelzer, Paulo de Tarso Müller

Article Affiliation:

Fernanda Viana Paulin

Abstract:

Purpose: There is evidence of complex interaction between vitamin B(vB) level, hyperhomocysteinemia (HyCy), and natriuretic peptide secretion. Exercise training could also modulate such interaction. In this secondary analysis of a Randomized Clinical Trial performed in a chronic obstructive pulmonary disease (COPD) rehabilitation setting, our primary objective was to investigate the interaction between vBsupplementation, exercise training, and changes in NT-proBNP levels after 8 weeks of intervention. Secondary objectives were to explore the correlations between acute changes in NT-proBNP levels with (i) acute exercise and (ii) oxygen uptake ('O) kinetics during rest-to-exercise transition.

Methods: Thirty-two subjects with COPD were randomized into four groups: Rehabilitation+vB(= 8), Rehabilitation (= 8), vB(= 8), or Maltodextrin(= 8). They were evaluated at baseline and after 8 weeks, during resting and immediately after maximal exercise constant work-rate tests (CWTs,lim), for NT-proBNP plasmatic levels.

Results: After interaction analysis, the supplementation with vBsignificantly changed the time course of NT-proBNP responses during treatment (= 0.048). However, the final analysis could not support a significant change in NT-proBNP levels owing to high-intensity constant work-rate exercise (-value>0.05). There was a statistically significant correlation between'Otime constant andΔNT-proBNP values (lim - rest) at baseline (= 0.049) and 2 months later (= 0.015), considering all subjects (= 32).

Conclusion: We conclude that vBsupplementation could modulate NT-proBNP secretion. Moreover, possibly, the slower the initial'Oadjustments toward a steady-state during rest-to-exercise transitions, the more severe the ventricular chamber volume/pressure stress recruitment, expressed through higher NT-proBNP secretion in subjects with larger'Otime constants, despite unchanged final acute exercise-induced neurohormone secretion.

Study Type : Human Study

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