Article Publish Status: FREE
Abstract Title:

Vitamin C Deficiency-Induced Pulmonary Arterial Hypertension.

Abstract Source:

Chest. 2020 Feb ;157(2):e21-e23. PMID: 32033656

Abstract Author(s):

Shameek K Gayen, Abd A Abdelrahman, Ioana R Preston, Raymond D Petit, Nicholas S Hill

Article Affiliation:

Shameek K Gayen


We report a case of a man in his 60s who developed pulmonary arterial hypertension (PAH) in association with profound vitamin C deficiency. Decreased availability of endothelial nitric oxide and activation of the hypoxia-inducible family of transcription factors, both consequences of vitamin C deficiency, are believed to be mechanisms contributing to the pathogenesis of the pulmonary hypertension. The PAH resolved following vitamin C supplementation. The current case highlights the importance of testing for vitamin C deficiency in patients with PAH in the proper clinical setting.

Study Type : Human: Case Report

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