Vitamin C (dehydroascorbic acid) and mixtures of vitamin E and beta-carotene possess antitumor properties upon radiation and increase the chemotherapeutic activity of mitomycin C. - GreenMedInfo Summary
Abstract Title:
Synergistic effect of dehydroascorbic acid and mixtures with vitamin E and beta-carotene on mitomycin C efficiency under irradiation in vitro.
Abstract Source:
In Vivo. 2004 Nov-Dec;18(6):795-8. PMID: 15646822
Abstract:
Experiments in vitro have shown that dehydroascorbic acid (DHA) possesses antitumor properties under irradiation, which are gradually enhanced by combination with beta-carotene or vitamin E. On the other hand the cytostatic efficiency of mitomycin C (MMC) is increased from deltaD37 = -93 up to deltaD37 = -141 in the presence of DHA. It has also been shown that Escherichia coli bacteria are able, to some extent, to reduce DHA to ascorbate under the same experimental conditions. The results are of interest for the radiation therapy of cancer.
Article Published Date : Nov 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : beta-Carotene : CK(541) : AC(99), Vitamin C : CK(6028) : AC(1399), Vitamin E : CK(3038) : AC(569)
Pharmacological Actions : Chemosensitizer : CK(1625) : AC(1251), Radiosensitizer : CK(291) : AC(238)
Additional Keywords : Drug-Plant-Vitamin Synergies : CK(965) : AC(266)
