Abstract Title:

Mitigation by vitamin C of the genotoxic effects of nicotine in mice, assessed by the comet assay and micronucleus induction.

Abstract Source:

Mutat Res. 2012 Feb 6. Epub 2012 Feb 6. PMID: 22331007

Abstract Author(s):

Vivian F S Kahl, Juliana M Reyes, Merielen S Sarmento, Juliana da Silva

Article Affiliation:

Laboratório de Genética Toxicológica, Universidade Luterana do Brasil, Canoas, RS, Brazil.


Nicotine has been reported to cause acute toxicity and to present long-term risks, such as chromosomal damage and genetic instability. The genotoxicity of nicotine may be mediated partly by an oxidative mechanism. We have evaluated the effects of the antioxidant vitamin C on nicotine-induced genotoxicity in mice. The comet assay and the micronucleus test were used to assess the effects of nicotine (15mg/kg) at different exposure times (2, 4, and 24h in the comet assay; 24h in the micronucleus test). Pretreatment with vitamin C 24h before nicotine exposure strongly protected mice against nicotine-induced DNA damage.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Genoprotective : CK(477) : AC(177)
Problem Substances : Nicotine : CK(71) : AC(18)
Adverse Pharmacological Actions : Genotoxic : CK(540) : AC(179)

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