Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes. - GreenMedInfo Summary
Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes.
Mol Cell Endocrinol. 2022 Aug 3:111740. Epub 2022 Aug 3. PMID: 35932980
Xiaoqin Luo
Dysregulation of adipose tissue involves increased cellular hypoxia, ER stress, and inflammation and altered adipokine production, contributing to the aetiology of obesity-related diseases including type 2 diabetes and cardiovascular disease. This study aimed to investigate the effects of Vitamin C supplementation on these processes in primary human preadipocytes and adipocytes. Treatment of preadipocytes and adipocytes with the proinflammatory cytokine TNFα and palmitic acid (PA), to mimic the obesogenic milieu, significantly increased markers of hypoxia, ER stress and inflammation and reduced secretion of high molecular weight (HMW) adiponectin. Importantly, Vitamin C abolished TNFα+PA induced hypoxia and significantly reduced the increases in ERstress and inflammation in both cell types. Vitamin C also significantly increased the secretion of HMW adiponectin from adipocytes. These findings indicate that Vitamin C can reduce obesity-associated cellular stress and thus provide a rationale for future investigations.