Abstract Title:

Vitamin C reverses bone loss in an osteopenic rat model of osteoporosis.

Abstract Source:

Int J Vitam Nutr Res. 2019 Mar 12:1-8. Epub 2019 Mar 12. PMID: 30859904

Abstract Author(s):

Farzad Deyhim, Kimberly Strong, Niaz Deyhim, Sarvenaz Vandyousefi, Alexis Stamatikos, Bahram Faraji

Article Affiliation:

Farzad Deyhim


Fruits and vegetables are rich in vitamin C with antioxidant properties which are known to influence bone quality. This study evaluated whether vitamin C (1000 mg/L) added to drinking water reverses the bone loss in ovariectomized rats. Ninety-day-old female Sprague-Dawley rats were randomly assigned to either sham (n = 14) or ovariecotmized groups (n = 28). Sixty days after ovariectomy, the treatments were sham, ovariectomy (OVX), OVX + vitamin C (22 mg oral intake daily) for 60 days. Urine was collected for deoxypyridinoline (DPD) evaluation, rats were sacrificed, and antioxidant capacity, osteopontin, alkaline phosphatase (ALP), and bone specific tartrate resistant acid phosphatase (TRAP) were evaluated in the plasma. Right femur and 5lumbar were evaluated for bone density, strength, ash, Ca, and Mg concentrations. Antioxidant capacity, ALP activity, osteopontin decreased (p-value<0.05), while TRAP and urinary DPD increased (p-value<0.05) with ovariectomy. In contrast, vitamin C increased (p-value<0.05) antioxidant capacity, ALP activity, osteopontin concentration and reduced (p-value<0.05) TRAP and urinary DPD excretion, respectively. Ovariectomy reduced (p-value<0.05) bone quality, bone ash, Ca and Mg concentrations. Vitamin C increased (p-value<0.05) femoral density without affecting (p-value>0.1) femoral strength, ash, or Ca, and Mg concentrations, while it increased (p-value<0.05) the 5lumbar density, ash, and Ca and Mg concentrations. In conclusion, vitamin C increased bone quality and antioxidant capacity in ovariectomized rats.

Study Type : Animal Study

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