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Article Publish Status: FREE
Abstract Title:

Vitamin D and curcumin-loaded PCL nanofibrous for engineering osteogenesis and immunomodulatory scaffold.

Abstract Source:

Front Bioeng Biotechnol. 2022 ;10:975431. Epub 2022 Aug 8. PMID: 36003534

Abstract Author(s):

Abdullrahman M Al-Bishari, Bilal A Al-Shaaobi, Aisha A Al-Bishari, Mohammed A Al-Baadani, Liang Yu, Jiating Shen, Lei Cai, Yiding Shen, Zhennan Deng, Peng Gao

Article Affiliation:

Abdullrahman M Al-Bishari

Abstract:

The accelerating bone healing process is still a major challenge in clinical orthopedics, especially in critical-sized bone defects. Recently, Nanofiber membranes are showing increasing attention in the biomedical field due to their good biocompatibility, mechanical stability, and the ability to work as a drug carrier to achieve localized and sustained drug delivery. Herein, a multifunction nanofiber membrane loaded with vitamin D (Vit D) and curcumin (Cur) was successfully fabricated using electrospinning technology. In addition, we innovatively modified Vit D with PEG to improve the hydrophilicity of PCL nanofibers. The vitro results of CCK-8, alkaline phosphatase (ALP) and mineralization demonstrated that the PCL/Vit D-Cur membrane had great potential for enhancing the proliferation/differentiation of osteoblasts. Moreover, the synergistic effect of Vit D-Cur loaded PCL nanofiber membrane showed a superior ability to improve the anti-inflammatory activity through M2 polarization. Furthermore,results confirmed that the defect treated with PCL/Vit D-Cur nanofiber membrane was filled with the newly formed bone after 1 month. These results indicate that the Vit D/Cur loaded membrane can be applied for potential bone regeneration therapy.

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