Abstract Title:

Vitamin D, Its Role in Recovery after Muscular Damage Following Exercise.

Abstract Source:

Nutrients. 2021 Jul 8 ;13(7). Epub 2021 Jul 8. PMID: 34371846

Abstract Author(s):

Alberto Caballero-García, Alfredo Córdova-Martínez, Néstor Vicente-Salar, Enrique Roche, Daniel Pérez-Valdecantos

Article Affiliation:

Alberto Caballero-García


Aside from its role in bone metabolism, vitamin D is a key immunomodulatory micronutrient. The active form of vitamin D (1,25(OH)D) seems to modulate the innate immune system through different mechanisms. The vitamin is involved in the differentiation of monocytes into macrophages, increasing the phagocytic and chemotactic functions of these cells. At the same time, vitamin D enables efferocytosis and prevents immunopathology. In addition, vitamin D is involved in other processes related to immune function, such as inflammation. Regarding muscle tissue, vitamin D plays an active role in muscle inflammatory response, protein synthesis, and regulation of skeletal muscle function. Two mechanisms have been proposed: A direct role of 1,25(OH)D binding to vitamin D receptors (VDRs) in muscle cells and the modulation of calcium transport in the sarcoplasmic reticulum. This second mechanism needs additional investigation. In conclusion, vitamin D seems to be effective in cases of deficiency and/or if there is a great muscular commitment, such as in high intensity exercises.

Study Type : Review

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