Abstract Title:

25-hydroxy Vitamin D Suppresses Hepatitis C Virus Replication and Contributes to Rapid Virological Response of Treatment Efficacy.

Abstract Source:

Hepatol Res. 2017 Feb 22. Epub 2017 Feb 22. PMID: 28225575

Abstract Author(s):

Jee-Fu Huang, Yu-Min Ko, Chung-Feng Huang, Ming-Lun Yeh, Chia-Yen Dai, Meng-Hsuan Hsieh, Ching-I Huang, Hua-Ling Yang, Shu-Chi Wang, Zu-Yau Lin, Shinn-Chern Chen, Ming-Lung Yu, Wan-Long Chuang

Article Affiliation:

Jee-Fu Huang


AIM: 25-hydroxy vitamin D (Vit D) plays a role in treatment outcomes in chronic hepatitis C virus (HCV) infection (CHC). We aimed to clarify HCV replication is inhibited by Vit D in HCV replicon cells. Clinical implication was assessed for rapid virological response (RVR) and sustained virological response (SVR) among those patients receiving anti-viral therapy.

METHODS: Cell survival and viral loads were observed in Con1 (genotype-1b) and J6/JFH (genotype-2a) cells treated with different doses of Vit D. Three groups of patients with different treatment responses were recruited to assess their Vit D levels: Group A (RVR-/SVR-); Group B (RVR+/SVR-); Group C (RVR+/SVR+).

RESULTS: The viral load of Con1 cells decreased by 69%, 80%, and 86%, in 1 μM, 5 μM, and 10 μM Vit D, respectively (p < 0.0001). In J6/JFH cells, it decreased by 12%, 55%, and 80.5% in 1 μM, 5 μM, and 10 μM Vit D, respectively (p < 0.0001). There was a significant increase of Vit D between CHC groups, ranging from 4.4 ± 5.6 ng/mL of group A (n = 44), 17.2 ± 11.6 ng/mL of group B (n = 44), to 32.5 ± 37.5 ng/mL of group C (n = 44) (P < 0.001). Advanced fibrosis (odds ratio = 0.13, 95% confidence interval = 0.04-0.41, P < 0.001) and Vit D deficiency (<10 ng/mL) (odds ratio = 0.11, 95% confidence interval = 0.03-0.43, P = 0.001) were predictive of SVR in the multivariate regression analysis.

CONCLUSION: Vit D decreases HCV replication and also contributes to early treatment viral kinetics.

Study Type : Human Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1307) : AC(596)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.