Article Publish Status: FREE
Abstract Title:

Association between vitamin D deficiency and insufficiency and the risk of childhood asthma: evidence from a meta-analysis.

Abstract Source:

Int J Clin Exp Med. 2015 ;8(4):5699-706. Epub 2015 Apr 15. PMID: 26131154

Abstract Author(s):

Lixin Man, Zhao Zhang, Meng Zhang, Yingying Zhang, Ju Li, Nan Zheng, Yanhua Cao, Ming Chi, Yujin Chao, Qiuer Huang, Chunmei Song, Bo Xu

Article Affiliation:

Lixin Man


OBJECTIVE: Whether vitamin D deficiency and insufficiency are associated with childhood asthma remains unclear. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of vitamin D deficiency and insufficiency and the risk of childhood asthma.

METHODS: Pertinent studies were identified by searching of PubMed and Web of Knowledge. The random effect model was used to combine the results. Meta-regression and subgroups analyses were used to explore potential sources of between-study heterogeneity. Publication bias was estimated using Egger's regression asymmetry test.

RESULTS: Finally, 14 articles with 15 studies including 3424 cases for vitamin D deficiency and 9 articles with 10 studies including 2756 cases for vitamin D insufficiency were included in this meta-analysis. The relative risk (95% confidence interval) of childhood asthma risk for vitamin D deficiency was 1.684 (1.321-2.148), and the associations were significant in America and Europe. Significant association of childhood asthma between vitamin D insufficiency and childhood asthma risk was found overall [1.577 (1.230-2.023)] and the subgroups of America, Europe and Asia. No evidence of significant publication bias between vitamin D deficiency and insufficiency and childhood asthma risk were found.

CONCLUSIONS: Results from this meta-analysis suggested that vitamin D deficiency and insufficiency might increase the risk of childhood asthma.

Study Type : Meta Analysis

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