Vitamin D deficiency and its metabolites can be a possible reason for HPVDNA persistence and related cervical intraepithelial neoplasia. - GreenMedInfo Summary

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Abstract Title:

Could 25-OH vitamin D deficiency be a reason for HPV infection persistence in cervical premalignant lesions?

Abstract Source:

J Exp Ther Oncol. 2016 Jul ;11(3):177-180. PMID: 28471122

Abstract Author(s):

Emre Özgü, Nafiye Yılmaz, Eralp Başer, Tayfun Güngör, Salim Erkaya, Halilİbrahim Yakut

Article Affiliation:

Emre Özgü

Abstract:

Vitamin D is an essential precursor to the steroid hormone calcitriol which mainly regulates calcium homeostasis. Moreover anti- proliferative, pro- apoptotic, anti- angiogenic effects of Vitamin D support the ideas of preventive role in various cancer. This study aimed to determine if there is a relationship between HPVDNA infection and cervical intraepithelial neoplasia and Vitamin D deficiency. As a result of the study the difference of 25-OH Vitamin D3 levels between HPVDNA positive group and the control group were statistically significant (p=0,009). According to results of our study, with the proven anti-inflammatory functions of Vitamin D, the deficiency of these molecule and its metabolites can be a possible reason for HPVDNA persistence and related cervical intraepithelial neoplasia.

Article Published Date : Jun 30, 2016
Study Type : Human Study
Additional Links
Substances : Vitamin D : CK(11151) : AC(1615)
Diseases : Cervical Neoplasia : CK(81) : AC(7), Human Papilloma Virus : CK(24) : AC(6), Vitamin D Deficiency : CK(5643) : AC(797)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(13987)
Additional Keywords : Increased Risk : CK(8421) : AC(1072), Risk Reduction : CK(17631) : AC(1963)

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Key Research Topics

Substance

Vitamin D

Disease

Vitamin D Deficiency
Cervical Neoplasia
Human Papilloma Virus

Pharmacological Actions

Anti-Inflammatory Agents

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