Abstract Title:

Vitamin D deficiency is associated with acute ischemic stroke, C-reactive protein, and short-term outcome.

Abstract Source:

Metab Brain Dis. 2016 Dec 14. Epub 2016 Dec 14. PMID: 27975188

Abstract Author(s):

Daniela Frizon Alfieri, Márcio Francisco Lehmann, Sayonara Rangel Oliveira, Tamires Flauzino, Francieli Delongui, Maria Caroline Martins de Araújo, Isaias Dichi, Vinícius Daher Delfino, Leda Mezzaroba, Andréa Name Colado Simão, Edna Maria Vissoci Reiche

Article Affiliation:

Daniela Frizon Alfieri


The aim of this study was to investigate whether vitamin D deficiency (VDD) is associated with acute ischemic stroke, inflammatory markers, and short-term outcome. 168 acute ischemic stroke patients and 118 controls were included. The modified Rankin Scale (mRS) was applied up to 8 h of admission (baseline) and after three-months follow-up, and blood samples were obtained up to 24 h of admission to evaluate serum levels of 25-hydroxivitamin D [25(OH)D] and inflammatory markers. Vitamin D levels classified the individuals in sufficient (VDS ≥ 30.0 ng/mL), insufficient(VDI 20.0-29.9 ng/mL), and deficient (VDD < 20.0 ng/mL) status. Patients had lower levels of 25(OH)D, higher frequency of VDD (43.45% vs. 5.08%, OR: 16.64, 95% CI: 5.66-42.92, p < 0.001), and higher inflammatory markers than controls (p < 0.05). Patients with VDD showed increased high sensitivity C-reactive protein (hsCRP) levels than those with VDS status (p = 0.043); those with poor outcome presented with lower 25(OH)D levels than those with good outcome (p = 0.008); moreover, 25(OH)D levels were negatively correlated with mRS after three-months follow-up (r = -0.239, p = 0.005). The associations between VDD and higher hsCRP levels and between 25(OH)D levels and poor outcome at short-term in acute ischemic stroke patients suggest the important role of vitamin D in the inflammatory response and pathophysiology of this ischemic event.

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