ASTHMA CONTROL STATUS AND LUNG FUNCTION IN RELATION TO VITAMIN D LEVEL IN CHILDREN WITH BRONCHIAL ASTHMA.
Georgian Med News. 2018 Oct(283):115-118. PMID: 30516505
The aim of the study - low circulating vitamin D level maybe related to poor asthma control status and decreased lung function. The aim of our research is to establish correlation between serum vitamin D level, asthma control status and lung function. The study was performed in children aged 6-15 years old, including patients with asthma (n=50), who referred to Sachkhere medical center for a visit. The status of asthma control in the basic group was classified as controlled (n=31) and uncontrolled (n=19). The children underwent serum vitamin D and IgE level, spirometry and skin prick tests for the study. Using the multivariate logistic regression analysis, the presence of asthma was associated with the reduced level of vitamin D (OR = 1.35, 95% CI (1,14-1.58) P = 0.011; χ2=6.78; F-0.022) in children with uncontrolled bronchial asthma. 48% of the patients in the group- controlled asthma (n=15) had vitamin D deficit, and in 52% of the cases (n=16) was confirmed with vitamin D insufficient. In the group -uncontrolled asthma - 5% of the patients (n=1) had Vitamin D insufficiency in blood serum. In 95% (n=18) of the patients vitamin D level was significantly low<20 ng/ml. According the results, decreased pulmonary function (p-0.039;χ2-3.12) is strongly associated with low level of vitamin D; but neither serum IgE level (p-0.54; χ2-10.9), nor skin prick test result on dust mite (p-0.50, χ2-5.12 ) was correlations with serum vitamin D low level. The presence of vitamin D deficiency effectively predict increased risk of uncontrolled bronchial asthma in children. Serum vitamin D level is related to lung function too. Therefore, the normalization of the serum levels of Vitamin D may have beneficial effect on improvement of asthma control in the complex of asthma management and preventive measures.