Vitamin D deficiency may be a marker of benign prostatic hyperplasia. - GreenMedInfo Summary
Vitamin D Deficiency as a Potential Marker of Benign Prostatic Hyperplasia.
Urology. 2016 Jun 17. Epub 2016 Jun 17. PMID: 27327576
OBJECTIVE: To determine whether prostatic volumes and urinary flow changes were higher in Chinese old men with vitamin D deficiency than in those without vitamin D deficiency.
METHODS: This was an observational case-control study of 224 old Chinese men. End-point variables were prostatic volume, measured by transrectal ultrasound, and urinary flow, measured by urinary flowmetry. The International Prostate Symptom Score (IPSS) and International Index of Erectile Function score were determined.
RESULTS: Two hundreds and thirty-one (71.7%) out of the 322 were defined as vitamin D deficiency. The vitamin D deficiency group had a significantly higher prostate volume (42 vs 28mL, P<0.001), aldosterone (293 vs 220 pg/ml, P<0.001) and prostate-specific antigen value (3.28 vs 2.55 ng/ml, p<0.001), and IPSS (4.47 vs 1.98, P<0.001) and a significantly lower maximum urinary flow (13.44 vs 29.98 ml/s, P<0.001) versus free of vitamin D deficiency group. Binary logistic regression analysis showed a strong association between the presence of vitamin D deficiency and BPH after adjusting for age, IPSS, urination time, urinary volume, abdominal obesity, aldosterone, glucose, insulin, parathyroid hormone, and c-reactive protein (OR 5.22, 95% CI 1.96-12.76, P=0.001).
CONCLUSION: There is a relationship between the presence of vitamin D deficiency and prostate growth-associated urinary symptoms, likely attributable to their pathophysiological similarity. This study suggests that vitamin D deficiency may be a marker of benign prostatic hyperplasia (BPH). Thus, it may be used as a future therapeutic target in patients with BPH. Further studies were necessary to confirm this association.