Abstract Title:

Myelofibrosis: an unusual presentation of vitamin D-deficient rickets.

Abstract Source:

Eur J Pediatr. 1999 Oct;158(10):828-9. PMID: 10486086

Abstract Author(s):

J L Stéphan, C Galambrun, A Dutour, F Freycon

Article Affiliation:

Paediatric Haematology and Oncology Unit, Hôpital Nord, Saint Etienne, F-42055, Cx02, France. [email protected]


We present the case of a breast-fed 5-month-old infant who presented with pancytopenia, secondary to intense myelofibrosis during the winter months because of undiagnosed rickets. The patient responded to oral vitamin D with rapid resolution of symptoms. Secondary hyperparathyroidism was the probable cause of the myelofibrosis. CONCLUSION: Although nutritional rickets remains a problem in developing countries, children in northern climates in industrialized countries may also be at risk. Rickets must be considered when assessing myelofibrosis in a very young child.

Study Type : Human: Case Report

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