The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis.
Gynecol Endocrinol. 2021 Jan 29:1-6. Epub 2021 Jan 29. PMID: 33508990
BACKGROUND: To our knowledge, data on the effects of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis are limited. This study was conducted to determine the effects of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis.
METHODS: The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients (aged 18-40 years old) with endometriosis. Participants were randomly allocated into two groups (30 participants each group) to receive either 50,000 IU vitamin D or placebo each 2 weeks for 12 weeks.
RESULTS: Vitamin D supplementation significantly decreased pelvic pain ( - 1.12; 95% CI, -2.1, -0.09;=.03) and total-/HDL-cholesterol ratio ( - 0.29; 95% CI, -0.57, -0.008;=.04) compared with the placebo. Moreover, vitamin D intake led to a significant reduction in high-sensitivity C-reactive protein (hs-CRP) ( - 0.64 mg/L; 95% CI, -0.97, -0.30;<.001) and a significant increase in total antioxidant capacity (TAC) (47.54 mmol/L; 95% CI, 19.98, 75.11;=.001) compared with the placebo.
CONCLUSIONS: Overall, our study demonstrated that vitamin D intake in patients with endometriosis resulted in a significant improvement of pelvic pain, total-/HDL-cholesterol ratio, hs-CRP and TAC levels, but did not affect other clinical symptoms and metabolic profiles.