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Article Publish Status: FREE
Abstract Title:

The Study of Correlation Between Serum Vitamin DConcentrations and HBV DNA Levels and Immune Response in Chronic Hepatitis Patients.

Abstract Source:

Nutrients. 2020 Apr 16 ;12(4). Epub 2020 Apr 16. PMID: 32316365

Abstract Author(s):

Wang-Sheng Ko, Yen-Ping Yang, Fang-Ping Shen, Mu-Chen Wu, Chia-Ju Shih, Mei-Chun Lu, Yuan-Horng Yan, Ya-Ling Chiou

Article Affiliation:

Wang-Sheng Ko

Abstract:

Chronic hepatitis B (CHB) is a common chronic disease. Previous studies have shown a link between 25-hydroxyvitamin D(vitamin D) concentration and liver disease. Hepatitis B virus (HBV) infection has been attributed to the inappropriate functioning of cell-mediated immunity. However, the effects of vitamin D, immune cell, and HBeAg status on HBV viral load in CHB patients are still unclear. We investigated the relationship between the serum concentration of vitamin D, percentage of immune cells in peripheral blood, and the HBV viral load of CHB patients. Sixty CHB patients were recruited, and their blood samples were collected and analyzed. Vitamin D level was measured using a chemiluminescence assay. A level of 30 ng/mL or above was defined as a vitamin Dsufficiency. We assigned vitamin Dstatus as either normal (≥30 ng/mL), insufficient (20-30 ng/mL), or deficient (<20 ng/mL). T-lymphocyte and B-lymphocyte surface markers in peripheral blood were detected using flow cytometry. The factors associated with HBV viral load were analyzed using univariate and multivariate-adjusted models. The mean serum vitamin Dconcentration in the subjects was 20.9±5.6 ng/mL. Up to 88.3% of the patients were either deficient in or had insufficient vitamin D. The gender, BMI, hepatitis B surface antigen levels, and ALT levels were significantly related to serum vitamin Dlevels. Serum vitamin Dconcentration, HBe status, HBs levels, ALT, and AST levels showed a statistically significant correlation with the HBV DNA levels. Serum vitamin Dconcentrations and hepatitis B surface antigen levels were strongly correlated with HBV DNA levels. Vitamin Dlevels were significantly associated with CD19 numbers (β:-6.2, 95% CI: -10.5). In multivariate analysis, vitamin Dlevels in the deficient and insufficient groups, and the CD8, HBeAg, and WBC counts were significantly associated with HBV DNA levels. In the immune tolerance phase of HBeAg-negative chronic HBV infection, vitamin Dmay be a modulator of immune function via CD8, CD19, and HBV DNA.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(4048) : AC(1475)

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Sayer Ji
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