Article Publish Status: FREE
Abstract Title:

Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR(-/-) and LDLR(+/+) mice.

Abstract Source:

Immun Inflamm Dis. 2017 Jun ;5(2):151-162. Epub 2017 Mar 13. PMID: 28474500

Abstract Author(s):

Ramiar Kheder, James Hobkirk, Zeayd Saeed, Justyna Janus, Sean Carroll, Michael J Browning, Cordula Stover

Article Affiliation:

Ramiar Kheder


INTRODUCTION: Fatty liver disease is prevalent in populations with high caloric intake. Nutritherapeutic approaches are being considered, such as supplementary Vitamin D3 , to improve aspects of metabolic syndrome, namely fatty liver disease, hyperlipidemia, and insulin resistance associated with obesity.

METHODS: We analyzed female LDLR(-/-) and LDLR(+/+) mice on a 10-week diabetogenic diet for markers of fatty liver disease, metabolic strain, and inflammation.

RESULTS: The groups on a high fat high sugar diet with supplementary Vitamin D3 , in comparison with the groups on a high fat high sugar diet alone, showed improved transaminase levels, significantly less hypertriglyceridemia and hyperinsulinemia, and histologically, there was less pericentral hepatic steatosis. Levels of non-esterified fatty acids and lipid peroxidation products were significantly lower in the group supplemented with additional Vitamin D3 , as were systemic markers of inflammation (serum endotoxin and IL-6). M2 macrophage phenotype predominated in the group supplemented with additional Vitamin D3 . Beneficial changes were observed as early as five weeks' supplementation with Vitamin D3 and extended to restoration of high fat high sugar diet induced decrease of bone mineral density.

CONCLUSION: In summary, Vitamin D3 was a significantly beneficial dietary additive to blunt a prediabetic phenotype in diet-induced obesity of female LDLR(-/-) and LDLR(+/+) mice.

Study Type : Animal Study

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