Abstract Title:

Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis.

Abstract Source:

J Dermatolog Treat. 2010 Jul 24. Epub 2010 Jul 24. PMID: 20653487

Abstract Author(s):

Mohammad Hassan Javanbakht, Seyed Ali Keshavarz, Mahmoud Djalali, Fereydoun Siassi, Mohammad Reza Eshraghian, Alireza Firooz, Hassan Seirafi, Amir Hooshang Ehsani, Maryam Chamari, Abbas Mirshafiey

Article Affiliation:

Department of Nutrition and Biochemistry, Faculty of Public Health.


Abstract Background: Atopic dermatitis is a chronically relapsing, highly pruritic and inflammatory skin disease. This study was done to assess the effects of vitamins D and E supplementation on the clinical manifestation of atopic dermatitis. Methods: Forty-five atopic dermatitis patients were included in a randomized, double-blind, placebo-controlled trial. They were randomly divided into four groups and treated for 60 days: group P (n = 11), vitamins D and E placebos; group D (n = 12), 1600 IU vitamin D(3) plus vitamin E placebo; group E (n = 11), 600 IU synthetic all-rac-alpha-tocopherol plus vitamin D placebo; and group DE (n = 11), 1600 IU vitamin D(3) plus 600 IU synthetic all-rac-alpha-tocopherol. Serum 25(OH) vitamin D and plasma alpha-tocopherol were determined before and after the trial. The clinical improvement was evaluated with SCORing Atopic Dermatitis (SCORAD). Data were analyzed by analysis of variance (ANOVA) and Kruskal-Wallis tests. Results: SCORAD was reduced after 60 days in groups D, E and DE by 34.8%, 35.7% and 64.3%, respectively (p = 0.004). Objective SCORAD also showed significant improvement. There was a positive correlation between SCORAD and intensity, objective, subjective and extent (p<0.001). We found a significant negative association between plasma alpha-tocopherol and SCORAD, intensity, objective and extent (p = 0.02). Conclusion: This study supports the contributing and beneficial effects of vitamins D and E in the treatment of atopic dermatitis.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & receive The Dark Side of Wheat Ebook

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.