Abstract Title:

Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease.

Abstract Source:

Ann N Y Acad Sci. 2009 May;1165:183-9. PMID: 15389648

Abstract Author(s):

Kleopas A Kleopa, Kyriacos Kyriacou, Eleni Zamba-Papanicolaou, Theodoros Kyriakides


We report a patient with late-onset celiac disease and neurological manifestations including myopathy, polyneuropathy, and ataxia. Laboratory investigations showed anti-gliadin antibodies and severe vitamin E deficiency. Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion-body myositis. A gluten-free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. Anti-gliadin antibodies were no longer present. This case illustrates the spectrum of neurological complications of celiac disease and documents the occurrence of reversible pathology resembling inclusion-body myopathy in the muscle.


Study Type : Human Study

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Sayer Ji
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