Abstract Title:

High-dose tocopherol acetate therapy in epidermolysis bullosa siblings of the Cockayne-Touraine type.

Abstract Source:

J Dermatol. 1993 Nov;20(11):723-5. PMID: 8300945

Abstract Author(s):

Y Shirakata, S Shiraishi, K Sayama, H Shinmori, Y Miki


We have employed a successful therapy for epidermolysis bullosa with high-dose oral tocopherol acetate. Two siblings with dominant dystrophic epidermolysis bullosa of the Cockayne-Touraine type were reported. Both siblings suffered from tense blisters and erosions healing with scars and transient milia on the extremities. Electron microscopic study of the blisters revealed a cleavage beneath the lamina densa in both siblings. High-dose oral tocopherol acetate therapy was administered to them with satisfactory clinical reduction of the blister formation.

Study Type : Human Study

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