Abstract Title:

Effect of vitamin E on aspirin-induced gastric mucosal injury in rats.

Abstract Source:

Dig Dis Sci. 2000 Mar;45(3):599-605. PMID: 10749339

Abstract Author(s):

N Sugimoto, N Yoshida, T Yoshikawa, Y Nakamuara, H Ichikawa, Y Naito, M Kondo

Article Affiliation:

Kyoto Prefectural University of Medicine, First Department of Internal Medicine, Japan.


We investigated the effect of vitamin E on aspirin-induced gastric mucosal injury in rats. Twenty-eight male Sprague-Dawley rats were divided into four groups and were fed for 20 weeks with a diet containing<0.1 mg/100 g of alpha-tocopherol (vitamin E-deficient), 2 mg/100 g of alpha-tocopherol (normal and vitamin E-sufficient), or 50 mg/100 g of alpha-tocopherol (vitamin E-supplemented). In vitamin E-deficient rats, oral administration of aspirin (200 mg/kg) plus HCI created more severe hemorrhagic erosions than in other rats. Vitamin E-deficient rats had higher levels of thiobarbituric acid reactive substances, myeloperoxidase activity, and cytokine-induced neutrophil chemoattractant in the gastric mucosa. Flow cytometry showed that CD18 expression on stimulated neutrophils was higher in vitamin E-deficient rats than in vitamin E-supplemented rats. These results suggest that vitamin E protects against aspirin-induced gastric mucosal injury by inhibiting lipid peroxidation and accumulation of activated neutrophils.

Study Type : Animal Study

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