Abstract Title:

Effects of chronic administration of vitamin E on haemodynamic responses to postural stress or cold pressor test in apparently healthy young men.

Abstract Source:

Niger Postgrad Med J.2008 Dec;15(4):225-8. PMID: 19169338

Abstract Author(s):

L A Olatunji, A O Soladoye


 OBJECTIVES: We sought to investigate the possible effect of chronic administration of vitamin E on haemodynamic responses to sympathetic stimulation and to test the hypothesis that chronic administration of vitamin E increases susceptibility to orthostatic intolerance. METHODS: Sympathetic stimulation was assessed by responses in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), forearm blood flow (FBF; venous occlusion plethysmography) and forearm vascular resistance (FVR) evoked by postural stress (600 head-up tilt; HUT) or cold pressor test (CPT) in 30 healthy young men before and after 4 weeks of vitamin E administration. CPT was induced by immersing a hand in water at 40 degrees C for 2 minutes. RESULTS: Administration of vitamin E reduced SBP (p<0.001), DBP (p<0.001), MAP (p<0.001), HR (p<0.001) and FVR (p<0.05) but increased FBF (p<0.01). Before vitamin E administration HUT increased HR (p<0.001). Conversely, HUT led to a decrease in HR (p<0.05) after vitamin E administration. The decreases in SBP (p<0.05) and FBF (p<0.05) with concomitant increases in DBP (p<0.001), MAP (p<0.001) and FVR (p<0.001) induced by HUT before vitamin E administration, were similar to those induced by HUT after vitamin E administration. The increases in SBP (p<0.001), DBP (p<0.001), MAP (p<0.001), HR (p<0.05), FVR (p<0.001) and a decrease in FBF (p<0.001) induced by CPT before vitamin E administration, were attenuated following vitamin E administration in these subjects. CONCLUSION: These results demonstrate that chronic administration of vitamin E significantly reversed HUT-induced tachycardia and prevented CPT-induced vascular and pressor responses. These findings suggest that vitamin E may exert cardioprotective effect presumably through enhanced cardiac vagal tone that may not be associated with poor orthostatic tolerance in young men.

Study Type : Human Study
Additional Links
Pharmacological Actions : Cardioprotective : CK(5377) : AC(1675)

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.