Abstract Title:

[Hepatocellular carcinoma and vitamin K2].

Abstract Source:

Clin Calcium. 2015 Nov ;25(11):1645-51. PMID: 26503869

Abstract Author(s):

Toshihiko Mizuta, Iwata Ozaki

Article Affiliation:

Toshihiko Mizuta


Despite recent progress in diagnosis and therapy, hepatocellular carcinoma(HCC)remains among the cancers with the poorest prognoses. Vitamin Ks(VKs)have been shown to suppress the growth of HCC cells. Long-term administration of VK2 has established its clinical safety, but it does not appear to exhibit marked anti-tumor effects when administered alone. For more effective use of VK2 against HCC, co-administration of VK2 with other proven anticancer agents or development of a new VK preparation with a modified side-chain should be investigated in the future.

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Sayer Ji
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