Abstract Title:

Effect of vitamin K in bone metabolism and vascular calcification: A review of mechanisms of action and evidences.

Abstract Source:

Crit Rev Food Sci Nutr. 2017 Dec 12 ;57(18):3959-3970. PMID: 27437760

Abstract Author(s):

Julia Khéde Dourado Villa, Marisa Alves Nogueira Diaz, Virgínia Ramos Pizziolo, Hércia Stampini Duarte Martino

Article Affiliation:

Julia Khéde Dourado Villa


Osteoporosis is a public health concern associated with an increased risk of bone fractures and vascular calcification. Vitamin K presents unique benefits on these issues, although understudied. The two main forms of vitamin K are phylloquinone (vitamin K) and menaquinone (vitamin K). In this study, it was especially investigated the action of vitamin Kin bones and vessels. Vitamin Khas shown to stimulate bone formation by promoting osteoblast differentiation and carboxylation of osteocalcin, and increasing alkaline phosphatase, insulin-like growth factor-1, growth differentiation factor-15, and stanniocalcin 2 levels. Furthermore, vitamin Kreduces the pro-apoptotic proteins Fas and Bax in osteoblasts, and decreases osteoclast differentiation by increasing osteoprotegerin and reducing the receptor activator of nuclear factor kappa-B ligand. In blood vessels, vitamin Kreduces the formation of hydroxyapatite, through the carboxylation of matrix Gla protein and Gla rich protein, inhibits the apoptosis of vascular smooth muscle cells, by increasing growth arrest-specific gene 6, and reduces the transdifferentiation of vascular smooth muscle cells to osteoblasts. The commonly used dosage of vitamin Kin human studies is 45 mg/day and its application can be an interesting strategy in benefitting bone and vascular health, especially to osteoporotic post-menopausal women.

Study Type : Review

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