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Abstract Title:

In vitro effects of bufotenine against RNA and DNA viruses.

Abstract Source:

Braz J Microbiol. 2021 Dec ;52(4):2475-2482. Epub 2021 Sep 25. PMID: 34562234

Abstract Author(s):

Camila Mosca Barboza, Daniel Carvalho Pimenta, Hugo Vigerelli, Andréa de Cássia Rodrigues da Silva, Jaíne Gonçalves Garcia, Raphaela Mello Zamudio, Juliana Galera Castilho, Jarbas Alves Montanha, Paulo Michel Roehe, Helena Beatriz de Carvalho Ruthner Batista

Article Affiliation:

Camila Mosca Barboza

Abstract:

Bufotenine, an alkaloid that can be found in plant extracts and skin secretions of amphibians, is reported to have potential antiviral activity. The present study evaluated the antiviral activity of bufotenine against different genetic lineages of rabies virus (RABV, a single-stranded, negative-sense RNA virus), canine coronavirus (CCoV, a positive-sense RNA virus) and two double-stranded DNA viruses (two strains of herpes simplex virus type 1/HSV-1 [KOS and the acyclovir-resistant HSV-1 strain 29R] and canine adenovirus 2, CAV-2). The maximal non-toxic bufotenine concentrations in Vero and BHK-21 cells were determined by MTT assays. The antiviral activity of bufotenine against each virus was assessed by examination of reductions in infectious virus titres and plaque assays. All experiments were performed with and without bufotenine, and the results were compared. Bufotenine demonstrated significant RABV inhibitory activity. No antiviral action was observed against CCoV, CAV-2 or HSV-1. These findings indicate that the antiviral activity of bufotenine is somewhat linked to the particular infectious dose used and the genetic lineage of the virus, although the mechanisms of its effects remain undetermined.

Study Type : In Vitro Study

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