Article Publish Status: FREE
Abstract Title:

In vivo assessment of the protection conferred byβ-glucans from Pleurotus ostreatus against the harmful effects of acrylamide intake (Part I).

Abstract Source:

Nutr Hosp. 2020 Aug 27 ;37(4):850-854. PMID: 32686446

Abstract Author(s):

Blanca Rosa Aguilar Uscanga, Adriana Cavazos Garduño, Josué R Solís Pacheco, Flavio Sandoval Garcia, Rosa Elena Navarro Hernández, Julio Serrano Niño

Article Affiliation:

Blanca Rosa Aguilar Uscanga


Introduction: acrylamide is formed in food through Maillard's reaction during thermal processing, and has been shown to be neurotoxic in humans, and a possible carcinogen. Studies have shown thatβ-glucans from Pleurotus ostreatus have diverse biological properties such as antioxidant and anticancer activities. Objective: the aim of this work was to evaluate the protective effect of β-glucans from Pleurotus ostreatus against the harmful effects of acrylamide consumption in mice. Methods: β-glucans were obtained by alkaline-acid hydrolysis of Pleurotus ostreatus, and the content was characterized by liquid chromatography. To evaluate the effect of β-glucans on the expression of glutathione, Balb/c mice were used, and 4 test groups were established. All groups were fed normally, and the groups treated with acrylamide were administered the compound intragastrically at a concentration of 50 g/mL; β-glucans were administered at a concentration of 50 g/mL. Results: mice exposed to acrylamide showed a marked variation in the activity of glutathione enzymes in the liver. Significant differences (p<0.05) were only found in the expression of glutathione transferase, which was increased almost 3 times in the group treated withβ-glucans as compared with the control group, and 1.5 times as compared with the group treated with acrylamide. Conclusions: the results show that β-glucans could act by increasing the activity of enzymes involved in xenobiotic detoxification, thus protecting the biological system against the harmful effects caused by acrylamide intake.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.