Article Publish Status: FREE
Abstract Title:

Walnut Consumption for Two Years and Leukocyte Telomere Attrition in Mediterranean Elders: Results of a Randomized Controlled Trial.

Abstract Source:

Nutrients. 2018 Dec 4 ;10(12). Epub 2018 Dec 4. PMID: 30518050

Abstract Author(s):

Tania-Marisa Freitas-Simoes, Montserrat Cofán, Maria A Blasco, Nora Soberón, Miguel Foronda, Mercè Serra-Mir, Irene Roth, Cinta Valls-Pedret, Mónica Doménech, Elena Ponferrada-Ariza, Carlos Calvo, Sujatha Rajaram, Joan Sabaté, Emilio Ros, Aleix Sala-Vila

Article Affiliation:

Tania-Marisa Freitas-Simoes


Randomized controlled trials on diet and shortening of leukocyte telomere length (LTL) mostly focus on marine-derived-3 polyunsaturated fatty acids (PUFA). Walnuts are a sustainable source of-3 PUFA. We investigated whether inclusion of walnuts (15% of energy) in the diet for 2 years would maintain LTL in cognitively healthy elders (63⁻79 years old) compared to a control group (habitual diet, abstaining from walnuts). This opportunistic sub-study was conducted within the Walnuts and Healthy Aging study, a dual-centre (Barcelona, Spain and Loma Linda University, California) parallel trial. A sub-set of the Barcelona site participants were randomly assigned to the walnut (= 80) or control group (= 69). We assessed LTL at baseline and at 2 years and we conducted repeated-measures ANCOVA with 2 factors: time (baseline, 2 years) and group (control, walnut) and their interaction. Adjusted means (95% confidence interval) of LTL (in kb) in controls were 7.360 (7.084,7.636) at baseline and 7.061 (6.835,7.288) after 2 years; corresponding values in the walnut group were 7.064 (6.807,7.320) and 7.074 (6.864,7.284). The time× intervention interaction was nearly significant (= 0.079), suggestive of a trend of walnut consumption in preserving LTL. This exploratory research finding should be confirmed in trials with adequate statistical power.

Study Type : Human Study
Additional Links
Pharmacological Actions : Telomere Protective : CK(231) : AC(29)

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