Article Publish Status: FREE
Abstract Title:

Therapeutic potential of Juglans regia L. leaf extract against diabetic retinopathy in rat.

Abstract Source:

Iran J Basic Med Sci. 2017 Nov ;20(11):1275-1281. PMID: 29299206

Abstract Author(s):

Davood Nasiry, Ali Reza Khalatbary, Hassan Ahmadvand

Article Affiliation:

Davood Nasiry


Objectives: Oxidative stress has a pivotal role in the pathogenesis of diabetic retinopathy (DR). Juglans regia L. (JRL) leaf extract has hypoglycemic and antioxidative properties. This study aimed to determine the ameliorative effects of JRL against diabetic retinopathy.

Materials and Methods: The DR rat model was generated by injection of streptozotocin (STZ). A subset of the diabetic rats received JRL or metformin after the onset of hyperglycemia. Histopathology and immunohistochemistry of apoptotic and inflammatory factors were assessed along with biochemical assessments of lipid peroxidation and antioxidant status.

Results: Lipid peroxidation level and catalase activity significantly improved after JRL consumption (P<0. 001). Degeneration of the retina attenuated after JRL consumption. Attenuation of the caspase-3, COX-2, PARP, and S100B expression could be detected significantly (P<0. 001) in the JRL-treated rats. While, blood glucose level decreased after JRL consumption (P<0. 001).

Conclusion: JRL leaf extract exert protective effects against diabetic retinopathy.

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & receive The Dark Side of Wheat Ebook

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.