Abstract Title:

Non-specific cytotoxicity of wheat gliadin components towards cultured human cells.

Abstract Source:

Lancet. 1976 Feb 14;1(7955):339-41. PMID: 54743

Abstract Author(s):

D A Hudson, H J Cornell, D R Purdham, C J Rolles


Chromatographically separated fractions of a proteolytic digest of wheat gliadin were assayed for cytotoxic properties using cultured human embryonic intestinal, lung, kidney, adrenal, and HEp-2 cells. In all cell types noxious effects were observed microscopically over a 24 h period. The most active fraction was that previously shown to produce xylose malabsorption in subjects with coeliac disease, disruption of lysosomes, and inhibition of morphological recovery of cultured mucosa from a patient on a gluten-free diet.

Study Type : In Vitro Study
Additional Links
Additional Keywords : Lectins : CK(73) : AC(40)
Problem Substances : Gliadin : CK(821) : AC(118)
Adverse Pharmacological Actions : Cytotoxic : CK(285) : AC(125)

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