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Abstract Title:

Whey protein enriched withfraction restores the pancreatic function of streptozotocin induced diabetic rats.

Abstract Source:

J Food Sci Technol. 2021 Feb ;58(2):805-810. Epub 2020 Sep 25. PMID: 33568874

Abstract Author(s):

Paula Gimenez Milani, Silvano Piovan, Yago Carvalho Lima, Maria Rosa Trentin Zorzenon, Carlos Vinicius Dalto da Rosa, Giuliana Maria Ledesma Peixoto, Paulo Cezar de Freitas Mathias, Maria Raquel Marçal Natali, Silvio Claudio da Costa, Cecília Edna Mareze-Costa

Article Affiliation:

Paula Gimenez Milani

Abstract:

The study aims to analyse the treatment of whey protein enriched withfraction in insulin secretion and its role mitigating streptozotocin-induced hyperglycemia in rats. Thus, diabetic animals were treated with whey protein enriched withfraction or with only the protein isolate or only the Stevia fraction. Insulin level in plasma was measured by radioimmunoassay and the viability ofβ cells was detected by immunohistochemistry. The results showed that diabetic animals treated with whey protein enriched withfraction had a greater recovery from insulinemia, with plasma levels similar to non-diabetic animals (~ 0.13 ng/mL). In addition, the same group showed a higher number of insulin-positive pancreatic B cells (~ 66%) in immunohistochemistry analysis, while the diabetic groups treated with only the fraction of stevia or whey protein showed 38 and 59% of positive cells, respectively. These results show that the treatment may have restored the viability of streptozotocin-injured pancreatic B cells, and consequently increased insulin secretion, suggesting whey protein enriched withfraction can be used an adjunct/supplement in diabetic treatment.

Study Type : Animal Study

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