Abstract Title:

Inhibition of HCV replicon cell growth by 2-arylbenzofuran derivatives isolated from Mori Cortex Radicis.

Abstract Source:

Planta Med. 2007 Nov;73(14):1481-5. Epub 2007 Oct 18. PMID: 17948170

Abstract Author(s):

Hyun Yong Lee, Ji Hyun Yum, Yang Kook Rho, Seong Jun Oh, Hyun Sik Choi, Hwan Bong Chang, Dong Hwa Choi, Moon-Jeong Leem, Eun Joo Choi, Jei Man Ryu, Soon Bong Hwang


Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection. In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the methanol extract of Mori Cortex Radicis was selected. Fractionation of the extract by monitoring antiviral activity with a replicon cell-based assay resulted in the isolation of five compounds, mulberroside C ( 1), moracin P ( 2), moracin O ( 3), moracin M ( 4) and mulberrofuran K ( 5) from the ethyl acetate-soluble fraction. Compounds 1 approximately 4 showed significant inhibitory activities. Compounds 2 and 3 showed potent inhibitory activity (IC (50) 35.6 microM, 80.8 microM, respectively) in the replicon cell assay, which was confirmed by NS3 helicase inhibitory activity (IC (50) 42.9 microM, 27.0 microM, respectively).

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)
Additional Keywords : Kampo Medicine : CK(1) : AC(1)

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