Abstract Title:

Antimicrobial activities of ethanol and butanol fractions of white rose petal extract.

Abstract Source:

Regul Toxicol Pharmacol. 2016 Jan 21 ;76:57-62. Epub 2016 Jan 21. PMID: 26802535

Abstract Author(s):

Dongsun Park, Kyungha Shin, Youngjin Choi, Haiyu Guo, Yeseul Cha, Sa-Hyun Kim, Nam Soo Han, Seong Soo Joo, Jae Kwon Choi, Yoon Bok Lee, Ehn-Kyoung Choi, Jong Bae Kim, Yun-Bae Kim

Article Affiliation:

Dongsun Park


White rose (Rosa hybrida) petals were extracted with ethanol (EtOH) or butanol (BuOH), and tested for their antimicrobial activities against two species of Gram-positive bacteria, six species of Gram-negative bacteria, and two species of fungi. On in vitro antimicrobial assays, Helicobacter pylori and Propionibacterium acnes were highly susceptible to white rose petal extract (WRPE)-EtOH and WRPE-BuOH, leading to minimal inhibitory concentrations of 100 and 10 μg/mL for H. pylori and 400 and 40 μg/mL for P. acnes, respectively. In in vivoexperiments, C57BL/6 mice were infected with H. pylori by intragastric inoculation (1 × 10(8) CFU/mouse) 3 times, and orally treated twice a day for 14 days with WRPE-EtOH and WRPE-BuOH. On a CLO kit assay, 200 mg/kg of WRPE-EtOH fully eliminated the bacteria from the gastric mucosa, and the effect of 100 mg/kg of ethanol fraction was similar to pantoprazole (30 mg/kg), displaying 75% elimination. WRPE-BuOH was more effective, exhibiting 75% elimination at 20 mg/kg. The CLO test results were confirmed by bacterial identification. WRPE-EtOH and WRPE-BuOH inhibited the growth of variousbacteria and fungi, and in particular, they effectively killed H. pylori and eliminated the bacteria from the mouse stomach. The results indicate that WRPE-EtOH and WRPE-BuOH could be good candidates for the elimination of H. pylori.

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