Abstract Title:

Effect of whole walnuts and walnut-skin extracts on oxidant status in mice.

Abstract Source:

Nutrition. 2010 Jul-Aug;26(7-8):823-8. Epub 2010 Jan 29. PMID: 20116211

Abstract Author(s):

Mónica Bulló, M Rosa Nogués, Patricia López-Uriarte, Jordi Salas-Salvadó, Marta Romeu

Article Affiliation:

Human Nutrition Unit, Department of Biochemistry and Biotechnology, Facultat de Medicinia i Ciències de la Salut, ISPV, Universitat Rovira i Virgili, Reus, Spain. [email protected]


OBJECTIVE: To evaluate the effect of the intake of whole walnuts and walnut fractions on the oxidant status in mice.

METHODS: Thirty-six C57BL/6J male mice were randomized to be fed one of three diets: 1) a standard diet (control group), 2) a standard diet with 10% of whole walnuts (walnut-diet group), or 3) a standard diet with 2% of walnut skins (walnut-skin-diet group) for 8 wk. The plasma antioxidant capacity was measured by oxygen radical-absorbance capacity and plasma ferric-reducing antioxidant potential. Conjugated diene formation and reduced glutathione levels were also analyzed.

RESULTS: We observed no changes in plasma oxidation capability between the walnut and walnut-skin groups with the exception of conjugated dienes. Plasma total antioxidant capacity and the ratio between reduced and oxidized forms of glutathione were lower in the walnut and walnut-skin groups than in the control group.

CONCLUSION: The decrease in the antioxidant burden observed in enzymatic and non-enzymatic antioxidant systems after sustained consumption of a whole-walnut or a walnut-skin diet in mice may be related to the plasma oxidation capability being maintained in the groups consuming the walnut diets.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856)

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