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Article Publish Status: FREE
Abstract Title:

Withaferin A-A Promising Phytochemical Compound with Multiple Results in Dermatological Diseases.

Abstract Source:

Molecules. 2021 Apr 21 ;26(9). Epub 2021 Apr 21. PMID: 33919088

Abstract Author(s):

Simona Bungau, Cosmin Mihai Vesa, Areha Abid, Tapan Behl, Delia Mirela Tit, Anamaria Lavinia Purza, Bianca Pasca, Laura Maghiar Todan, Laura Endres

Article Affiliation:

Simona Bungau

Abstract:

Withaferin A (WFA) was identified as the most active phytocompound of the plant() and as having multiple therapeutic/ameliorating properties (anticancer, antiangiogenic, anti-invasive, anti-inflammatory, proapoptotic, etc.) in case of various diseases. In drug chemistry, WFA in silico approaches have identified favorite biological targets, stimulating and accelerating research to evaluate its pharmacological activity-numerous anticancer effects manifested in various organs (breast, pancreas, skin, colon, etc.), antivirals, anti-infective, etc., which are not yet sufficiently explored. This paper is a synthesis of the most relevant specialized papers in the field that are focused on the use of WFA in dermatological diseases, describing its mechanism of action while providing, at the same time, details about the results of its testing in in vitro/in vivo studies.

Study Type : Review

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