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Article Publish Status: FREE
Abstract Title:

Withania somnifera as an Adjunctive Treatment for Refractory Restless Legs Syndrome in Parkinson's Disease: A Case Report.

Abstract Source:

Cureus. 2021 Dec ;13(12):e20775. Epub 2021 Dec 28. PMID: 35111460

Abstract Author(s):

Kaustubh S Chaudhari, Rakesh R Tiwari, Saurabh S Chaudhari, Swati V Joshi, Harish B Singh

Article Affiliation:

Kaustubh S Chaudhari

Abstract:

Non-motor symptoms of Parkinson's disease (PD), such as insomnia and restless legs syndrome (RLS), tend to worsen and become refractory as neurodegeneration progresses. We report the case of a 72-year-old female with a six-year history of PD and two-and-half-year history of insomnia and refractory RLS. We added a neuroprotective agent,, to the existing treatment regimen for her insomnia. Besides the partial remission of her insomnia and motor symptoms of PD, there was a complete reversal of the RLS symptoms.has been shown to improve PD symptoms by preventing oxidative damage of the nigrostriatal dopaminergic neurons and improving dopamine levels in the midbrain and corpus striatum. Our case provides the first-time evidence whereadded for insomnia caused a complete remission of refractory RLS, possibly due to its anti-apoptotic and pro-dopaminergic actions.could prove beneficial in cases where the disease advances but further addition of dopamine agonists for refractory RLS is not possible due to the risk of dopamine augmentation.

Study Type : Human: Case Report

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