Women diagnosed with DCIS or stage I disease have similar mortality to controls. - GreenMedInfo Summary
Causes of death and relative survival of older women after a breast cancer diagnosis.
J Clin Oncol. 2011 Apr 20 ;29(12):1570-7. Epub 2011 Mar 14. PMID: 21402602
Beth Israel Deaconess Medical Center, 1309 Beacon St, Office 202, Brookline, MA 02446, USA. firstname.lastname@example.org
PURPOSE: To understand the impact of breast cancer on older women's survival, we compared survival of older women diagnosed with breast cancer with matched controls. METHODS Using the linked 1992 to 2003 Surveillance, Epidemiology, and End Results (SEER) -Medicare data set, we identified women age 67 years or older who were newly diagnosed with ductal carcinoma in situ (DCIS) or breast cancer. We identified women not diagnosed with breast cancer from the 5% random sample of Medicare beneficiaries residing in SEER areas. We matched patient cases to controls by birth year and registry (97% or 64,894 patient cases matched successfully). We assigned the start of follow-up for controls as the patient cases' date of diagnosis. Mortality data were available through 2006. We compared survival of women with breast cancer by stage with survival of controls using multivariable proportional hazards models adjusting for age at diagnosis, comorbidity, prior mammography use, and sociodemographics. We repeated these analyses stratifying by age.
RESULTS: Median follow-up time was 7.8 years. Differences between patient cases and controls in sociodemographics and comorbidities were small (<4%). Women diagnosed with DCIS (adjusted hazard ratio [aHR], 0.9; 95% CI, 0.8 to 0.9) or stage I disease (aHR, 1.0; 95% CI, 1.0 to 1.0) had similar mortality to controls. Women diagnosed with stage II disease or higher had greater mortality than controls (stage II disease: aHR, 1.5; 95% CI, 1.5 to 1.6). The association of a breast cancer diagnosis with mortality declined with age among women with advanced disease.
CONCLUSION: Compared with matched controls, a diagnosis of DCIS or stage I breast cancer in older women is associated with similar survival, whereas a diagnosis of stage II or higher breast cancer is associated with worse survival.