Abstract Title:

Latent celiac disease in reproductive performance of women.

Abstract Source:

Fertil Steril. 2010 Nov 22. Epub 2010 Nov 22. PMID: 21106194

Abstract Author(s):

Ashok Kumar, Mamta Meena, Nargis Begum, Nirmal Kumar, Ram Kumar Gupta, Sarita Aggarwal, Sudha Prasad, Swaraj Batra

Article Affiliation:

Department of Obstetrics and Gynecology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.


OBJECTIVE: To investigate the prevalence of positive serologic findings for celiac disease in Indian women with poor reproductive performance. DESIGN: Cross-sectional except that the women with intrauterine growth restriction were followed prospectively until delivery. SETTING: Department of Obstetrics and Gynecology of a tertiary teaching hospital, New Delhi. PATIENT(S): Eight hundred ninety-three women (104 women with idiopathic recurrent abortion, 104 women with unexplained stillbirth, 230 cases of unexplained infertility, 150 pregnant women with idiopathic intrauterine growth restriction, 305 control cases). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The presence of antigliadin IgA and IgG, anti-tissue transglutaminase IgA by ELISA, and IgA antiendomysium antibody by indirect immunofluorescence microscopy. RESULT(S): The seroprevalence of transglutaminase IgA was 6.70% in the group with recurrent abortion, 5.70% in the group with stillbirth, 5.65% in the group with infertility, 9.33% in the group with intrauterine growth restriction, and 1.30% in the control group. Rates of previous preterm births, low-birth-weight infants, and cesarean section were higher in seropositive women compared with seronegative subjects. CONCLUSION(S): Women having poor reproductive performance had subclinical celiac disease. The serology for celiac disease can be considered in idiopathic cases.

Study Type : Human Study

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